› 112d

X-ray diffraction
2.5Å resolution

MOLECULAR STRUCTURE OF THE G.A BASE PAIR IN DNA AND ITS IMPLICATIONS FOR THE MECHANISM OF TRANSVERSION MUTATIONS

Released:
DOI: 10.2210/pdb112d/pdb
PDB entry 112d coloured by chain, front view.
PDB entry 112d coloured by chain, side view.
PDB entry 112d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Molecular structure of the G.A base pair in DNA and its implications for the mechanism of transversion mutations.
Brown T, Hunter WN, Kneale G, Kennard O
Proc Natl Acad Sci U S A 83 2402-6 (1986)
PMID: 3458205

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113304 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*AP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.69 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 25.69Å b: 41.96Å c: 65.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 not available not available
Expression system: Not provided

Quick links

Citations

13 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
12 more

22 mentions without citation

Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.
Nicolaou et al. (2012)
21 more