› 168d

X-ray diffraction
2Å resolution

STABILIZING EFFECTS OF THE RNA 2'-SUBSTITUENT: CRYSTAL STRUCTURE OF AN OLIGODEOXYNUCLEOTIDE DUPLEX CONTAINING 2'-O-METHYLATED ADENOSINES

Released:
DOI: 10.2210/pdb168d/pdb
PDB entry 168d coloured by chain, front view.
PDB entry 168d coloured by chain, side view.
PDB entry 168d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.
Lubini P, Zürcher W, Egli M
Chem Biol 1 39-45 (1994)
PMID: 9383369

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113049 (preferred)
Entry contents:
1 distinct DNA/RNA hybrid molecule
Macromolecule:
DNA/RNA (5'-D(*GP*CP*GP*TP*)-R(*(A2M)P*)-D(*TP*AP*CP*GP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.08 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand A2M 2 x A2M

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-21
Spacegroup: P212121
Unit cell:
a: 25.13Å b: 45.649Å c: 47.554Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 not available not available
Expression system: Not provided

Quick links

Citations

16 review citations

Antisense oligonucleotides: the next frontier for treatment of neurological disorders.
Rinaldi et al. (2018)
15 more

5 mentions without citation

PDBSiteScan: a program for searching for active, binding and posttranslational modification sites in the 3D structures of proteins.
Ivanisenko et al. (2004)
4 more