› 184d

X-ray diffraction
1.8Å resolution

SELF-ASSOCIATION OF A DNA LOOP CREATES A QUADRUPLEX: CRYSTAL STRUCTURE OF D(GCATGCT) AT 1.8 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb184d/pdb
PDB entry 184d coloured by chain, front view.
PDB entry 184d coloured by chain, side view.
PDB entry 184d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Self-association of a DNA loop creates a quadruplex: crystal structure of d(GCATGCT) at 1.8 A resolution.
Leonard GA, Zhang S, Peterson MR, Harrop SJ, Helliwell JR, Cruse WB, d'Estaintot BL, Kennard O, Brown T, Hunter WN
Structure 3 335-40 (1995)
PMID: 7613864

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113362 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*CP*AP*TP*GP*CP*T)-3') Chain: A
Molecule details ›
Chain: A
Length: 7 nucleotides
Theoretical weight: 2.11 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C222
Unit cell:
a: 22.52Å b: 59.37Å c: 24.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 not available
Expression system: Not provided

Quick links

Citations

9 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
8 more

7 mentions without citation

Non-G Base Tetrads.
Escaja et al. (2022)
6 more