› 1a29

X-ray diffraction
2.74Å resolution

CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)

Released:
DOI: 10.2210/pdb1a29/pdb
PDB entry 1a29 coloured by chain, front view.
PDB entry 1a29 coloured by chain, side view.
PDB entry 1a29 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies.
Vertessy BG, Harmat V, Böcskei Z, Náray-Szabó G, Orosz F, Ovádi J
Biochemistry 37 15300-10 (1998)
PMID: 9799490

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P62157 (Residues: 2-149; Coverage: 99%)
Gene names: CALM, CAM
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand TFP 2 x TFP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P3221
Unit cell:
a: 40.75Å b: 40.75Å c: 177.57Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.197 0.265

Quick links

Citations

3 review citations

S100 proteins as therapeutic targets.
Bresnick AR. (2018)
2 more

26 mentions without citation

SuperPose: a simple server for sophisticated structural superposition.
Maiti et al. (2004)
25 more