› 1a3p

Solution NMR

ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1a3p/pdb
PDB entry 1a3p coloured by chain, ensemble of 20 models, front view.
PDB entry 1a3p coloured by chain, ensemble of 20 models, side view.
PDB entry 1a3p coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.
Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T, Nice EC, Norton RS
Protein Sci 7 1738-49 (1998)
PMID: 10082370

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134050 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor Chain: A
Molecule details ›
Chain: A
Length: 45 amino acids
Theoretical weight: 4.88 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P01132 (Residues: 980-1024; Coverage: 4%)
Gene name: Egf
Sequence domains: EGF-like domain
Structure domains: Laminin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ABA 2 x ABA

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

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Citations

3 review citations

Growth factors: possible roles for clinical management of the short bowel syndrome.
McMellen et al. (2010)
2 more