› 1a7x

X-ray diffraction
2Å resolution

FKBP12-FK1012 COMPLEX

Released:
DOI: 10.2210/pdb1a7x/pdb
PDB entry 1a7x coloured by chain, front view.
PDB entry 1a7x coloured by chain, side view.
PDB entry 1a7x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12.
Schultz LW, Clardy J
Bioorg Med Chem Lett 8 1-6 (1998)
PMID: 9871618

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP1A Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand FKA 1 x FKA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: C2221
Unit cell:
a: 133.59Å b: 40.51Å c: 93.13Å
α: 90° β: 90° γ: 90°
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Targeting protein function: the expanding toolkit for conditional disruption.
Campbell et al. (2016)
1 more

9 mentions without citation

FKBP Ligands-Where We Are and Where to Go?
Kolos et al. (2018)
8 more