› 1a8j

X-ray diffraction
2.7Å resolution

IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME

Released:
DOI: 10.2210/pdb1a8j/pdb
PDB entry 1a8j coloured by chain, front view.
PDB entry 1a8j coloured by chain, side view.
PDB entry 1a8j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Treatment of osteoarthritis with aspartame.
Edmundson AB, Manion CV
Clin Pharmacol Ther 63 580-93 (1998)
PMID: 9630831

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134491 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin lambda variable 2-8 Chains: H, L
Molecule details ›
Chains: H, L
Length: 216 amino acids
Theoretical weight: 22.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01709 (Residues: 20-118; Coverage: 100%)
Gene name: IGLV2-8
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand PME 2 x PME
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P3121
Unit cell:
a: 72.3Å b: 72.3Å c: 185.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.22 0.38

Quick links

Citations

8 citation in other articles

Binding of nascent collagen by amyloidogenic light chains and amyloid fibrillogenesis in monolayers of human fibrocytes.
Harris et al. (2000)
7 more

4 mentions without citation

Statistical analysis of physical-chemical properties and prediction of protein-protein interfaces.
Negi et al. (2007)
3 more