› 1aa9

Solution NMR

HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE

Released:
DOI: 10.2210/pdb1aa9/pdb
PDB entry 1aa9 coloured by chain, front view.
PDB entry 1aa9 coloured by chain, side view.
PDB entry 1aa9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein.
Ito Y, Yamasaki K, Iwahara J, Terada T, Kamiya A, Shirouzu M, Muto Y, Kawai G, Yokoyama S, Laue ED, Wälchli M, Shibata T, Nishimura S, Miyazawa T
Biochemistry 36 9109-19 (1997)
PMID: 9230043

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133956 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase HRas Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01112 (Residues: 1-171; Coverage: 91%)
Gene names: HRAS, HRAS1
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Structure-function relationships of the G domain, a canonical switch motif.
Wittinghofer et al. (2011)
20 more

3 mentions without citation

Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation.
Chen et al. (2006)
2 more