› 1ad6

X-ray diffraction
2.3Å resolution

DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR

Released:
DOI: 10.2210/pdb1ad6/pdb
PDB entry 1ad6 coloured by chain, front view.
PDB entry 1ad6 coloured by chain, side view.
PDB entry 1ad6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box.
Kim HY, Cho Y
Nat. Struct. Biol. 4 390-5 (1997)
PMID: 9145110

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoblastoma-associated protein Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 21.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06400 (Residues: 378-562; Coverage: 20%)
Gene name: RB1
Sequence domains: Retinoblastoma-associated protein A domain
Structure domains: Cyclin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 38.6Å b: 68.04Å c: 80.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.201 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.
Mendenhall et al. (1998)
11 more

14 mentions without citation

Finding weak similarities between proteins by sequence profile comparison.
Panchenko AR. (2003)
13 more