› 1adz

Solution NMR

THE SOLUTION STRUCTURE OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR, NMR, 30 STRUCTURES

Released:
DOI: 10.2210/pdb1adz/pdb
PDB entry 1adz coloured by chain, ensemble of 30 models, front view.
PDB entry 1adz coloured by chain, ensemble of 30 models, side view.
PDB entry 1adz coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
Burgering MJ, Orbons LP, van der Doelen A, Mulders J, Theunissen HJ, Grootenhuis PD, Bode W, Huber R, Stubbs MT
J Mol Biol 269 395-407 (1997)
PMID: 9199408

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tissue factor pathway inhibitor Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 8.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10646 (Residues: 107-182; Coverage: 26%)
Gene names: LACI, TFPI, TFPI1
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DIANA
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Adaptation of ticks to a blood-feeding environment: evolution from a functional perspective.
Mans et al. (2004)
6 more

6 mentions without citation

THESEUS: maximum likelihood superpositioning and analysis of macromolecular structures.
Theobald et al. (2006)
5 more