› 1ae5

X-ray diffraction
2.3Å resolution

HUMAN HEPARIN BINDING PROTEIN

Released:
DOI: 10.2210/pdb1ae5/pdb
PDB entry 1ae5 coloured by chain, front view.
PDB entry 1ae5 coloured by chain, side view.
PDB entry 1ae5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of HBP, a multifunctional protein with a serine proteinase fold.
Iversen LF, Kastrup JS, Bjørn SE, Rasmussen PB, Wiberg FC, Flodgaard HJ, Larsen IK
Nat Struct Biol 4 265-8 (1997)
PMID: 9095193

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Azurocidin Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 24.3 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P20160 (Residues: 27-251; Coverage: 97%)
Gene name: AZU1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P212121
Unit cell:
a: 39.19Å b: 66.12Å c: 101.36Å
α: 90° β: 90° γ: 90°
Expression system: unidentified baculovirus

Quick links

Citations

5 review citations

Neutrophil-derived azurocidin alarms the immune system.
Soehnlein et al. (2009)
4 more

2 mentions without citation

Differentially expressed genes in Hirudo medicinalis ganglia after acetyl-L-carnitine treatment.
Federighi et al. (2013)
1 more