› 1aik

X-ray diffraction
2Å resolution

HIV GP41 CORE STRUCTURE

Released:
DOI: 10.2210/pdb1aik/pdb
PDB entry 1aik coloured by chain, front view.
PDB entry 1aik coloured by chain, side view.
PDB entry 1aik coloured by chain, top view.
Source organism: HIV-1 M:B_HXB2R
Primary publication:
Core structure of gp41 from the HIV envelope glycoprotein.
Chan DC, Fass D, Berger JM, Kim PS
Cell 89 263-73 (1997)
PMID: 9108481

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137977 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chain: N
Molecule details ›
Chain: N
Length: 37 amino acids
Theoretical weight: 4.15 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 546-581; Coverage: 4%)
Gene name: env
Transmembrane protein gp41 Chain: C
Molecule details ›
Chain: C
Length: 35 amino acids
Theoretical weight: 4.28 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 627-661; Coverage: 4%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P321
Unit cell:
a: 49.5Å b: 49.5Å c: 55.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.238 0.238 0.266
Expression system: Escherichia coli

Quick links

Citations

221 review citations

Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.
Skehel et al. (2000)
220 more

90 mentions without citation

Virus membrane fusion.
Weissenhorn et al. (2007)
89 more