› 1alg

Solution NMR

SOLUTION STRUCTURE OF AN HGR INHIBITOR, NMR, 10 STRUCTURES

Released:
DOI: 10.2210/pdb1alg/pdb
PDB entry 1alg coloured by chain, ensemble of 10 models, front view.
PDB entry 1alg coloured by chain, ensemble of 10 models, side view.
PDB entry 1alg coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
Denaturation and reactivation of dimeric human glutathione reductase--an assay for folding inhibitors.
Nordhoff A, Tziatzios C, van den Broek JA, Schott MK, Kalbitzer HR, Becker K, Schubert D, Schirmer RH
Eur J Biochem 245 273-82 (1997)
PMID: 9151953

Function and Biology Details

Reaction catalysed: 
2 glutathione + NADP(+) = glutathione disulfide + NADPH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione reductase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 24 amino acids
Theoretical weight: 2.44 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P00390 (Residues: 480-503; Coverage: 5%)
Gene names: GLUR, GRD1, GSR

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

7 review citations

Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions.
Becker et al. (2004)
6 more