› 1aly

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND

Released:
DOI: 10.2210/pdb1aly/pdb
PDB entry 1aly coloured by chain, front view.
PDB entry 1aly coloured by chain, side view.
PDB entry 1aly coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2 A crystal structure of an extracellular fragment of human CD40 ligand.
Karpusas M, Hsu YM, Wang JH, Thompson J, Lederman S, Chess L, Thomas D
Structure 3 1031-9 (1995)
PMID: 8589998

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD40 ligand, soluble form Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 15.81 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P29965 (Residues: 116-261; Coverage: 56%)
Gene names: CD40L, CD40LG, TNFSF5, TRAP
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: R3
Unit cell:
a: 77.17Å b: 77.17Å c: 90.46Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.223 0.295
Expression system: Komagataella pastoris

Quick links

Citations

39 review citations

Molecular mechanism and function of CD40/CD40L engagement in the immune system.
Elgueta et al. (2009)
38 more

32 mentions without citation

Protein cage assembly across multiple length scales.
Aumiller et al. (2018)
31 more