› 1ang

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN REVEALS THE STRUCTURAL BASIS FOR ITS FUNCTIONAL DIVERGENCE FROM RIBONUCLEASE

Released:
DOI: 10.2210/pdb1ang/pdb
PDB entry 1ang coloured by chain, front view.
PDB entry 1ang coloured by chain, side view.
PDB entry 1ang coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease.
Acharya KR, Shapiro R, Allen SC, Riordan JF, Vallee BL
Proc Natl Acad Sci U S A 91 2915-9 (1994)
PMID: 8159679

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 83.4Å b: 120.6Å c: 37.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 not available
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Mechanisms of action of angiogenin.
Gao et al. (2008)
9 more

19 mentions without citation

Angiogenin and Copper Crossing in Wound Healing.
Cucci et al. (2021)
18 more