› 1aox

X-ray diffraction
2.1Å resolution

I DOMAIN FROM INTEGRIN ALPHA2-BETA1

Released:
DOI: 10.2210/pdb1aox/pdb
PDB entry 1aox coloured by chain, front view.
PDB entry 1aox coloured by chain, side view.
PDB entry 1aox coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the I domain from integrin alpha2beta1.
Emsley J, King SL, Bergelson JM, Liddington RC
J Biol Chem 272 28512-7 (1997)
PMID: 9353312

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 203 amino acids
Theoretical weight: 22.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P17301 (Residues: 169-365, 366-367; Coverage: 17%)
Gene names: CD49B, ITGA2
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 40.54Å b: 43.29Å c: 68.04Å
α: 88.27° β: 76.59° γ: 66.74°
R-values:
R R work R free
0.219 0.219 not available
Expression system: Escherichia coli BL21

Quick links

Citations

34 review citations

Integrins: bidirectional, allosteric signaling machines.
Hynes RO. (2002)
33 more

20 mentions without citation

Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.
Shimaoka et al. (2001)
19 more