› 1apj

Solution NMR

NMR STUDY OF THE TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-LIKE DOMAIN (TB MODULE/8-CYS DOMAIN), NMR, 21 STRUCTURES

Released:
DOI: 10.2210/pdb1apj/pdb
PDB entry 1apj coloured by chain, ensemble of 21 models, front view.
PDB entry 1apj coloured by chain, ensemble of 21 models, side view.
PDB entry 1apj coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils.
Yuan X, Downing AK, Knott V, Handford PA
EMBO J 16 6659-66 (1997)
PMID: 9362480

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152940 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrillin-1 Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35555 (Residues: 2052-2125; Coverage: 3%)
Gene names: FBN, FBN1
Sequence domains: TB domain
Structure domains: TGF-beta binding (TB) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

24 review citations

The molecular genetics of Marfan syndrome and related disorders.
Robinson et al. (2006)
23 more

5 mentions without citation

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.
Saharinen et al. (2000)
4 more