› 1ath

X-ray diffraction
3.2Å resolution

THE INTACT AND CLEAVED HUMAN ANTITHROMBIN III COMPLEX AS A MODEL FOR SERPIN-PROTEINASE INTERACTIONS

Released:
DOI: 10.2210/pdb1ath/pdb
PDB entry 1ath coloured by chain, front view.
PDB entry 1ath coloured by chain, side view.
PDB entry 1ath coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions.
Schreuder HA, de Boer B, Dijkema R, Mulders J, Theunissen HJ, Grootenhuis PD, Hol WG
Nat Struct Biol 1 48-54 (1994)
PMID: 7656006

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antithrombin-III Chains: A, B
Molecule details ›
Chains: A, B
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 90.95Å b: 101.17Å c: 69.519Å
α: 90° β: 105.96° γ: 90°
R-values:
R R work R free
0.179 0.179 not available
Expression system: Not provided

Quick links

Citations

26 review citations

What do dysfunctional serpins tell us about molecular mobility and disease?
Stein et al. (1995)
25 more

5 mentions without citation

Serpins in arthropod biology.
Meekins et al. (2017)
4 more