› 1avh

X-ray diffraction
2.3Å resolution

CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN ANNEXIN V AFTER REFINEMENT. IMPLICATIONS FOR STRUCTURE, MEMBRANE BINDING AND ION CHANNEL FORMATION OF THE ANNEXIN FAMILY OF PROTEINS

Released:
DOI: 10.2210/pdb1avh/pdb
PDB entry 1avh coloured by chain, front view.
PDB entry 1avh coloured by chain, side view.
PDB entry 1avh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.
Huber R, Berendes R, Burger A, Schneider M, Karshikov A, Luecke H, Römisch J, Paques E
J Mol Biol 223 683-704 (1992)
PMID: 1311770

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-140372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 320 amino acids
Theoretical weight: 35.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08758 (Residues: 1-320; Coverage: 100%)
Gene names: ANX5, ANXA5, ENX2, PP4
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P63
Unit cell:
a: 98.8Å b: 98.8Å c: 129Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.184 not available
Expression system: Not provided

Quick links

Citations

22 review citations

Annexins: linking Ca2+ signalling to membrane dynamics.
Gerke et al. (2005)
21 more

6 mentions without citation

Normal-modes-based prediction of protein conformational changes guided by distance constraints.
Zheng et al. (2005)
5 more