› 1awb

X-ray diffraction
2.5Å resolution

HUMAN MYO-INOSITOL MONOPHOSPHATASE IN COMPLEX WITH D-INOSITOL-1-PHOSPHATE AND CALCIUM

Released:
DOI: 10.2210/pdb1awb/pdb
PDB entry 1awb coloured by chain, front view.
PDB entry 1awb coloured by chain, side view.
PDB entry 1awb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of an Enzyme-Substrate Complex and the Catalytic Mechanism of Human Brain Myo-Inositol Monophosphatase
Ganzhorn AJ, Rondeau J-M
Protein Eng. 10 61- (1997)

Function and Biology Details

Reactions catalysed: 
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol monophosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 30.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29218 (Residues: 2-277; Coverage: 100%)
Gene names: IMPA, IMPA1
Sequence domains: Inositol monophosphatase family
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CA 6 x CA
Ligand CL 2 x CL
Ligand IPD 2 x IPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE M18X
Spacegroup: P3221
Unit cell:
a: 86.37Å b: 86.37Å c: 153.795Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.153 0.153 0.189
Expression system: Escherichia coli

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