› 1awi

X-ray diffraction
2.2Å resolution

HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE

Released:
DOI: 10.2210/pdb1awi/pdb
PDB entry 1awi coloured by chain, front view.
PDB entry 1awi coloured by chain, side view.
PDB entry 1awi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation.
Mahoney NM, Janmey PA, Almo SC
Nat Struct Biol 4 953-60 (1997)
PMID: 9360613

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139732 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Profilin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 14.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07737 (Residues: 3-140; Coverage: 99%)
Gene name: PFN1
Sequence domains: Profilin
Structure domains: Dynein light chain 2a, cytoplasmic
L-PRO10 Chain: P
Molecule details ›
Chain: P
Length: 10 amino acids
Theoretical weight: 989 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21212
Unit cell:
a: 68.25Å b: 97.64Å c: 39.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.305
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

19 review citations

Allergic rhinitis and its impact on asthma.
Bousquet et al. (2001)
18 more

7 mentions without citation

Structure and functions of profilins.
Krishnan et al. (2009)
6 more