› 1ayd

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

Released:
DOI: 10.2210/pdb1ayd/pdb
PDB entry 1ayd coloured by chain, front view.
PDB entry 1ayd coloured by chain, side view.
PDB entry 1ayd coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Lee CH, Kominos D, Jacques S, Margolis B, Schlessinger J, Shoelson SE, Kuriyan J
Structure 2 423-38 (1994)
PMID: 7521735

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.53 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P35235 (Residues: 4-103; Coverage: 17%)
Gene name: Ptpn11
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 63.2Å b: 63.2Å c: 76.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 not available
Expression system: Not provided

Quick links

Citations

30 review citations

Protein modules and signalling networks.
Pawson T. (1995)
29 more

7 mentions without citation

Characterization of the fast dynamics of protein amino acid side chains using NMR relaxation in solution.
Igumenova et al. (2006)
6 more