› 1azx

X-ray diffraction
2.9Å resolution

ANTITHROMBIN/PENTASACCHARIDE COMPLEX

Released:
DOI: 10.2210/pdb1azx/pdb
PDB entry 1azx coloured by chain, front view.
PDB entry 1azx coloured by chain, side view.
PDB entry 1azx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The anticoagulant activation of antithrombin by heparin.
Jin L, Abrahams JP, Skinner R, Petitou M, Pike RN, Carrell RW
Proc Natl Acad Sci U S A 94 14683-8 (1997)
PMID: 9405673

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Antithrombin-III Chains: I, L
Molecule details ›
Chains: I, L
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: Z9L, Z9K, GU6, GU1, Z9H
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P21
Unit cell:
a: 70.44Å b: 86.97Å c: 97.22Å
α: 90° β: 108.88° γ: 90°
R-values:
R R work R free
0.203 0.195 0.28

Quick links

Citations

75 review citations

Heparin-protein interactions.
Capila et al. (2002)
74 more

13 mentions without citation

Demystifying heparan sulfate-protein interactions.
Xu et al. (2014)
12 more