› 1b0r

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF HLA-A*0201 COMPLEXED WITH A PEPTIDE WITH THE CARBOXYL-TERMINAL GROUP SUBSTITUTED BY A METHYL GROUP

Released:
DOI: 10.2210/pdb1b0r/pdb
PDB entry 1b0r coloured by chain, front view.
PDB entry 1b0r coloured by chain, side view.
PDB entry 1b0r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of HLA-A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal group substituted by a methyl group.
Bouvier M, Guo HC, Smith KJ, Wiley DC
Proteins 33 97-106 (1998)
PMID: 9741848

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137711 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
PROTEIN (INFLUENZA MATRIX PEPTIDE) Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 922 Da

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CDE 1 x CDE

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 49.6Å b: 74.4Å c: 121.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.253 0.314
Expression system: Escherichia coli

Quick links

Citations

2 review citations

MHC superfamily structure and the immune system.
Maenaka et al. (1999)
1 more

6 mentions without citation

Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: implications for vaccine design.
Borbulevych et al. (2005)
5 more