› 1b3o

X-ray diffraction
2.9Å resolution

TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE

Released:
DOI: 10.2210/pdb1b3o/pdb
PDB entry 1b3o coloured by chain, front view.
PDB entry 1b3o coloured by chain, side view.
PDB entry 1b3o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.
Colby TD, Vanderveen K, Strickler MD, Markham GD, Goldstein BM
Proc Natl Acad Sci U S A 96 3531-6 (1999)
PMID: 10097070

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 514 amino acids
Theoretical weight: 55.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12268 (Residues: 1-514; Coverage: 100%)
Gene names: IMPD2, IMPDH2
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments


Cofactor: Ligand SAE 2 x SAE
2 bound ligands:
Ligand CPR 2 x CPR
Ligand UNX 15 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: I4
Unit cell:
a: 142.26Å b: 142.26Å c: 174.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.244 0.27
Expression system: Escherichia coli

Quick links

Citations

13 review citations

CBS domains: structure, function, and pathology in human proteins.
Ignoul et al. (2005)
12 more

9 mentions without citation

IMP dehydrogenase: structure, mechanism, and inhibition.
Hedstrom L. (2009)
8 more