› 1b6c

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12

Released:
DOI: 10.2210/pdb1b6c/pdb
PDB entry 1b6c coloured by chain, front view.
PDB entry 1b6c coloured by chain, side view.
PDB entry 1b6c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.
Huse M, Chen YG, Massagué J, Kuriyan J
Cell 96 425-36 (1999)
PMID: 10025408

Function and Biology Details

Reactions catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-153251 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP1A Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3
TGF-beta receptor type-1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 342 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36897 (Residues: 162-503; Coverage: 73%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P1
Unit cell:
a: 75.58Å b: 81.06Å c: 90.53Å
α: 86.23° β: 81.86° γ: 63.92°
R-values:
R R work R free
0.249 0.249 0.269
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

Quick links

Citations

95 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
94 more

63 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
62 more