› 1bbc

X-ray diffraction
2.2Å resolution

STRUCTURE OF RECOMBINANT HUMAN RHEUMATOID ARTHRITIC SYNOVIAL FLUID PHOSPHOLIPASE A2 AT 2.2 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1bbc/pdb
PDB entry 1bbc coloured by chain, front view.
PDB entry 1bbc coloured by chain, side view.
PDB entry 1bbc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution.
Wery JP, Schevitz RW, Clawson DK, Bobbitt JL, Dow ER, Gamboa G, Goodson T, Hermann RB, Kramer RM, McClure DB
Nature 352 79-82 (1991)
PMID: 2062381

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146964 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholipase A2, membrane associated Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P14555 (Residues: 21-144; Coverage: 100%)
Gene names: PLA2B, PLA2G2A, PLA2L, RASF-A
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 31.61Å b: 54.56Å c: 31.32Å
α: 90° β: 97.2° γ: 90°
R-values:
R R work R free
0.178 0.178 not available
Expression system: Not provided

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Citations

27 review citations

The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
Six et al. (2000)
26 more

4 mentions without citation

Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics.
Faure et al. (2007)
3 more