› 1bfi

Solution NMR

SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES

Released:
DOI: 10.2210/pdb1bfi/pdb
PDB entry 1bfi coloured by chain, ensemble of 30 models, front view.
PDB entry 1bfi coloured by chain, ensemble of 30 models, side view.
PDB entry 1bfi coloured by chain, ensemble of 30 models, top view.
Source organism: Bos taurus
Primary publication:
Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
Siegal G, Davis B, Kristensen SM, Sankar A, Linacre J, Stein RC, Panayotou G, Waterfield MD, Driscoll PC
J Mol Biol 276 461-78 (1998)
PMID: 9512716

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.75 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23727 (Residues: 614-724; Coverage: 15%)
Gene name: PIK3R1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Structure and function of phosphoinositide 3-kinases.
Wymann et al. (1998)
4 more

1 mention without citation

Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.
Gabelli et al. (2010)