› 1bqu

X-ray diffraction
2Å resolution

CYTOKYNE-BINDING REGION OF GP130

Released:
DOI: 10.2210/pdb1bqu/pdb
PDB entry 1bqu coloured by chain, front view.
PDB entry 1bqu coloured by chain, side view.
PDB entry 1bqu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a cytokine-binding region of gp130.
Bravo J, Staunton D, Heath JK, Jones EY
EMBO J 17 1665-74 (1998)
PMID: 9501088

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154046 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-6 receptor subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 24.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40189 (Residues: 119-333; Coverage: 24%)
Gene name: IL6ST
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 6 x SO4
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2221
Unit cell:
a: 84.48Å b: 132.295Å c: 121.933Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.255
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Structural biology of shared cytokine receptors.
Wang et al. (2009)
11 more

15 mentions without citation

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.
LaPorte et al. (2008)
14 more