› 1bx4

X-ray diffraction
1.5Å resolution

STRUCTURE OF HUMAN ADENOSINE KINASE AT 1.50 ANGSTROMS

Released:
DOI: 10.2210/pdb1bx4/pdb
PDB entry 1bx4 coloured by chain, front view.
PDB entry 1bx4 coloured by chain, side view.
PDB entry 1bx4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human adenosine kinase at 1.5 A resolution.
Mathews II, Erion MD, Ealick SE
Biochemistry 37 15607-20 (1998)
PMID: 9843365

Function and Biology Details

Reaction catalysed: 
ATP + adenosine = ADP + AMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157283 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine kinase Chain: A
Molecule details ›
Chain: A
Length: 345 amino acids
Theoretical weight: 38.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55263 (Residues: 20-362; Coverage: 95%)
Gene name: ADK
Sequence domains: pfkB family carbohydrate kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand MG 3 x MG
Ligand ADN 2 x ADN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21212
Unit cell:
a: 65.3Å b: 111.08Å c: 49.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.226
Expression system: Escherichia coli

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Citations

11 review citations

The structural and biochemical foundations of thiamin biosynthesis.
Jurgenson et al. (2009)
10 more

22 mentions without citation

Development of Novel Anti-Leishmanials: The Case for Structure-Based Approaches.
Soni et al. (2022)
21 more