› 1by7

X-ray diffraction
2Å resolution

HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2. LOOP (66-98) DELETION MUTANT

Released:
DOI: 10.2210/pdb1by7/pdb
PDB entry 1by7 coloured by chain, front view.
PDB entry 1by7 coloured by chain, side view.
PDB entry 1by7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function.
Harrop SJ, Jankova L, Coles M, Jardine D, Whittaker JS, Gould AR, Meister A, King GC, Mabbutt BC, Curmi PM
Structure 7 43-54 (1999)
PMID: 10368272

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138521 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 2 Chain: A
Molecule details ›
Chain: A
Length: 382 amino acids
Theoretical weight: 43.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05120 (Residues: 1-415; Coverage: 92%)
Gene names: PAI2, PLANH2, SERPINB2
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 138.82Å b: 41.73Å c: 77.4Å
α: 90° β: 114.88° γ: 90°
R-values:
R R work R free
0.202 0.202 0.268
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Conformational pathology of the serpins: themes, variations, and therapeutic strategies.
Gooptu et al. (2009)
4 more

4 mentions without citation

Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21).
Lampl et al. (2010)
3 more