› 1c07

Solution NMR

STRUCTURE OF THE THIRD EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15

Released:
DOI: 10.2210/pdb1c07/pdb
PDB entry 1c07 coloured by chain, ensemble of 20 models, front view.
PDB entry 1c07 coloured by chain, ensemble of 20 models, side view.
PDB entry 1c07 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.
Enmon JL, de Beer T, Overduin M
Biochemistry 39 4309-19 (2000)
PMID: 10757979

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor substrate 15 Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42566 (Residues: 217-311; Coverage: 11%)
Gene names: AF1P, EPS15
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

6 review citations

Biological basket weaving: formation and function of clathrin-coated vesicles.
Brodsky et al. (2001)
5 more

9 mentions without citation

Role of the retinal vascular endothelial cell in ocular disease.
Bharadwaj et al. (2013)
8 more