› 1cbs

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID

Released:
DOI: 10.2210/pdb1cbs/pdb
PDB entry 1cbs coloured by chain, front view.
PDB entry 1cbs coloured by chain, side view.
PDB entry 1cbs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.
Kleywegt GJ, Bergfors T, Senn H, Le Motte P, Gsell B, Shudo K, Jones TA
Structure 2 1241-58 (1994)
PMID: 7704533

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular retinoic acid-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29373 (Residues: 2-138; Coverage: 99%)
Gene name: CRABP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand REA 1 x REA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 45.65Å b: 47.56Å c: 77.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Fold change in evolution of protein structures.
Grishin NV. (2001)
18 more

31 mentions without citation

The photochemical determinants of color vision: revealing how opsins tune their chromophore's absorption wavelength.
Wang et al. (2014)
30 more