› 1cjm

X-ray diffraction
2.4Å resolution

HUMAN SULT1A3 WITH SULFATE BOUND

Released:
DOI: 10.2210/pdb1cjm/pdb
PDB entry 1cjm coloured by chain, front view.
PDB entry 1cjm coloured by chain, side view.
PDB entry 1cjm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human catecholamine sulfotransferase.
Bidwell LM, McManus ME, Gaedigk A, Kakuta Y, Negishi M, Pedersen L, Martin JL
J Mol Biol 293 521-30 (1999)
PMID: 10543947

Function and Biology Details

Reaction catalysed: 
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase 1A3 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DMM9 (Residues: 1-295; Coverage: 100%)
Gene names: STM, SULT1A3
Sequence domains: Sulfotransferase domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3221
Unit cell:
a: 56.4Å b: 56.4Å c: 191.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.276 0.276 0.288
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Human sulfotransferases and their role in chemical metabolism.
Gamage et al. (2006)
11 more

8 mentions without citation

The structural biology of oestrogen metabolism.
Thomas et al. (2013)
7 more