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Solution NMR

IMMUNOGLOBULIN MOTIF DNA-RECOGNITION AND HETERODIMERIZATION FOR THE PEBP2/CBF RUNT-DOMAIN

Released:
DOI: 10.2210/pdb1cmo/pdb
PDB entry 1cmo coloured by chain, ensemble of 43 models, front view.
PDB entry 1cmo coloured by chain, ensemble of 43 models, side view.
PDB entry 1cmo coloured by chain, ensemble of 43 models, top view.
Source organism: Homo sapiens
Primary publication:
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.
Nagata T, Gupta V, Sorce D, Kim WY, Sali A, Chait BT, Shigesada K, Ito Y, Werner MH
Nat Struct Biol 6 615-9 (1999)
PMID: 10404214

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Runt-related transcription factor 1 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01196 (Residues: 52-178; Coverage: 28%)
Gene names: AML1, CBFA2, RUNX1
Sequence domains: Runt domain
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: HYBRID DISTANCE GEOMETRY/SIMULATED ANNEALING
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Core-binding factors in haematopoiesis and leukaemia.
Speck et al. (2002)
22 more

4 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
3 more