› 1cnt

X-ray diffraction
2.4Å resolution

CILIARY NEUROTROPHIC FACTOR

Released:
DOI: 10.2210/pdb1cnt/pdb
PDB entry 1cnt coloured by chain, front view.
PDB entry 1cnt coloured by chain, side view.
PDB entry 1cnt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.
McDonald NQ, Panayotatos N, Hendrickson WA
EMBO J 14 2689-99 (1995)
PMID: 7796798

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150747 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ciliary neurotrophic factor Chains: 1, 2, 3, 4
Molecule details ›
Chains: 1, 2, 3, 4
Length: 187 amino acids
Theoretical weight: 21.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26441 (Residues: 1-187; Coverage: 94%)
Gene name: CNTF
Sequence domains: Ciliary neurotrophic factor
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand YB 1 x YB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 52.95Å b: 62.09Å c: 208.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.199 0.247
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
Heinrich et al. (1998)
14 more

6 mentions without citation

The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.
Plun-Favreau et al. (2001)
5 more