› 1cok

Solution NMR

STRUCTURE OF THE C-TERMINAL DOMAIN OF P73

Released:
DOI: 10.2210/pdb1cok/pdb
PDB entry 1cok coloured by chain, ensemble of 18 models, front view.
PDB entry 1cok coloured by chain, ensemble of 18 models, side view.
PDB entry 1cok coloured by chain, ensemble of 18 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.
Chi SW, Ayed A, Arrowsmith CH
EMBO J 18 4438-45 (1999)
PMID: 10449409

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127438 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein p73 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15350 (Residues: 487-554; Coverage: 11%)
Gene names: P73, TP73
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

30 review citations

p73: Friend or foe in tumorigenesis.
Melino et al. (2002)
29 more

6 mentions without citation

Structure and apoptotic function of p73.
Yoon et al. (2015)
5 more