› 1cqp

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION

Released:
DOI: 10.2210/pdb1cqp/pdb
PDB entry 1cqp coloured by chain, front view.
PDB entry 1cqp coloured by chain, side view.
PDB entry 1cqp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.
Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U
J Mol Biol 292 1-9 (1999)
PMID: 10493852

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-L Chains: A, B
Molecule details ›
Chains: A, B
Length: 182 amino acids
Theoretical weight: 20.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20701 (Residues: 153-334; Coverage: 16%)
Gene names: CD11A, ITGAL
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand 803 2 x 803
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P212121
Unit cell:
a: 72.7Å b: 77.7Å c: 91.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.257
Expression system: Not provided

Quick links

Citations

48 review citations

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
47 more

10 mentions without citation

Advances, interactions, and future developments in the CNS, Phenix, and Rosetta structural biology software systems.
Adams et al. (2013)
9 more