› 1cs3

X-ray diffraction
2Å resolution

STRUCTURE OF BTB/POZ TRANSCRIPTION REPRESSION DOMAIN FROM PROMELOCYTIC LEUKEMIA ZINC FINGER ONCOPROTEIN

Released:
DOI: 10.2210/pdb1cs3/pdb
PDB entry 1cs3 coloured by chain, front view.
PDB entry 1cs3 coloured by chain, side view.
PDB entry 1cs3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.
Li X, Peng H, Schultz DC, Lopez-Guisa JM, Rauscher FJ, Marmorstein R
Cancer Res 59 5275-82 (1999)
PMID: 10537309

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-170214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger and BTB domain-containing protein 16 Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05516 (Residues: 7-122; Coverage: 17%)
Gene names: PLZF, ZBTB16, ZNF145
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: I222
Unit cell:
a: 38.8Å b: 78.2Å c: 85.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.272
Expression system: Escherichia coli

Quick links

Citations

7 review citations

All in the family: the BTB/POZ, KRAB, and SCAN domains.
Collins et al. (2001)
6 more

2 mentions without citation

Sequence and structural analysis of BTB domain proteins.
Stogios et al. (2005)
1 more