› 1csg

X-ray diffraction
2.7Å resolution

Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor

Released:
DOI: 10.2210/pdb1csg/pdb
PDB entry 1csg coloured by chain, front view.
PDB entry 1csg coloured by chain, side view.
PDB entry 1csg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.
Walter MR, Cook WJ, Ealick SE, Nagabhushan TL, Trotta PP, Bugg CE
J Mol Biol 224 1075-85 (1992)
PMID: 1569568

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137437 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Granulocyte-macrophage colony-stimulating factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04141 (Residues: 18-144; Coverage: 100%)
Gene names: CSF2, GMCSF
Sequence domains: Granulocyte-macrophage colony-stimulating factor
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 46.6Å b: 58.8Å c: 126.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.254 not available
Expression system: Not provided

Quick links

Citations

11 review citations

Interleukin-6: structure-function relationships.
Simpson et al. (1997)
10 more

7 mentions without citation

Role of the β Common (βc) Family of Cytokines in Health and Disease.
Hercus et al. (2018)
6 more