› 1csk

X-ray diffraction
2.5Å resolution

THE CRYSTAL STRUCTURE OF HUMAN CSKSH3: STRUCTURAL DIVERSITY NEAR THE RT-SRC AND N-SRC LOOP

Released:
DOI: 10.2210/pdb1csk/pdb
PDB entry 1csk coloured by chain, front view.
PDB entry 1csk coloured by chain, side view.
PDB entry 1csk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop.
Borchert TV, Mathieu M, Zeelen JP, Courtneidge SA, Wierenga RK
FEBS Lett 341 79-85 (1994)
PMID: 7511113

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase CSK Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 71 amino acids
Theoretical weight: 7.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P41240 (Residues: 1-71; Coverage: 16%)
Gene name: CSK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 64.9Å b: 74.69Å c: 125.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.278
Expression system: Not provided

Quick links

Citations

4 review citations

Regulation, substrates and functions of src.
Brown et al. (1996)
3 more

11 mentions without citation

Native protein sequences are close to optimal for their structures.
Kuhlman et al. (2000)
10 more