› 1ctr

X-ray diffraction
2.45Å resolution

DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX

Released:
DOI: 10.2210/pdb1ctr/pdb
PDB entry 1ctr coloured by chain, front view.
PDB entry 1ctr coloured by chain, side view.
PDB entry 1ctr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex.
Cook WJ, Walter LJ, Walter MR
Biochemistry 33 15259-65 (1994)
PMID: 7803388

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin-1 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P0DP23 (Residues: 2-149; Coverage: 99%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand TFP 1 x TFP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 41Å b: 41Å c: 178.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 not available
Expression system: Not provided

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Citations

4 review citations

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers.
Vasile et al. (2020)
3 more

38 mentions without citation

Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering.
Tria et al. (2015)
37 more