› 1d2j

Solution NMR

LDL RECEPTOR LIGAND-BINDING MODULE 6

Released:
DOI: 10.2210/pdb1d2j/pdb
PDB entry 1d2j coloured by chain, ensemble of 20 models, front view.
PDB entry 1d2j coloured by chain, ensemble of 20 models, side view.
PDB entry 1d2j coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the sixth LDL-A module of the LDL receptor.
North CL, Blacklow SC
Biochemistry 39 2564-71 (2000)
PMID: 10704205

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01130 (Residues: 233-272; Coverage: 5%)
Gene name: LDLR
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING IN TORSION ANGLE SPACE FOLLOWED BY SIMULATED ANNEALING REFINEMENT IN 3D COORDINATE SPACE.
Expression system: Escherichia coli BL21

Quick links

Citations

9 review citations

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Lillis et al. (2008)
8 more

3 mentions without citation

Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Dagil et al. (2013)
2 more