› 1d3e

Electron Microscopy
28Å resolution

CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 16 (HRV16) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY

Released:
DOI: 10.2210/pdb1d3e/pdb
PDB entry 1d3e coloured by chain, front view.
PDB entry 1d3e coloured by chain, side view.
PDB entry 1d3e coloured by chain, top view.
Source organisms:
Primary publication:
Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor.
Kolatkar PR, Bella J, Olson NH, Bator CM, Baker TS, Rossmann MG
EMBO J 18 6249-59 (1999)
PMID: 10562537

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138637 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Intercellular adhesion molecule 1 Chain: I
Molecule details ›
Chain: I
Length: 185 amino acids
Theoretical weight: 20.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05362 (Residues: 28-212; Coverage: 37%)
Gene name: ICAM1
Sequence domains: Intercellular adhesion molecule (ICAM), N-terminal domain
Capsid protein VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 285 amino acids
Theoretical weight: 32.31 KDa
Source organism: Human rhinovirus sp.
UniProt:
  • Canonical: Q82122 (Residues: 569-853; Coverage: 13%)
Sequence domains: picornavirus capsid protein
Capsid protein VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 252 amino acids
Theoretical weight: 27.91 KDa
Source organism: Human rhinovirus sp.
UniProt:
  • Canonical: Q82122 (Residues: 79-330; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: 3
Molecule details ›
Chain: 3
Length: 238 amino acids
Theoretical weight: 26.31 KDa
Source organism: Human rhinovirus sp.
UniProt:
  • Canonical: Q82122 (Residues: 331-568; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP4 Chain: 4
Molecule details ›
Chain: 4
Length: 68 amino acids
Theoretical weight: 7.37 KDa
Source organism: Human rhinovirus sp.
UniProt:
  • Canonical: Q82122 (Residues: 2-69; Coverage: 3%)
Sequence domains: Picornavirus coat protein (VP4)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 28Å

Quick links

Citations

35 review citations

Foot-and-mouth disease.
Grubman et al. (2004)
34 more

3 mentions without citation

Evolution of cell recognition by viruses: a source of biological novelty with medical implications.
Baranowski et al. (2003)
2 more