› 1d7p

X-ray diffraction
1.5Å resolution

Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A

Released:
DOI: 10.2210/pdb1d7p/pdb
PDB entry 1d7p coloured by chain, front view.
PDB entry 1d7p coloured by chain, side view.
PDB entry 1d7p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the C2 domain of human factor VIII at 1.5 A resolution.
Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL
Nature 402 439-42 (1999)
PMID: 10586887

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Factor VIIIa light chain Chain: M
Molecule details ›
Chain: M
Length: 159 amino acids
Theoretical weight: 18.06 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P00451 (Residues: 2190-2348; Coverage: 7%)
Gene names: F8, F8C
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand CYS 1 x CYS
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200, ALS BEAMLINE 5.0.2, NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 46.44Å b: 56.41Å c: 65.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.215
Expression system: Saccharomyces cerevisiae

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Citations

41 review citations

Mammalian collagen receptors.
Leitinger et al. (2007)
40 more

22 mentions without citation

Protein-protein docking benchmark version 3.0.
Hwang et al. (2008)
21 more