› 1d9n

Solution NMR

SOLUTION STRUCTURE OF THE METHYL-CPG-BINDING DOMAIN OF THE METHYLATION-DEPENDENT TRANSCRIPTIONAL REPRESSOR MBD1/PCM1

Released:
DOI: 10.2210/pdb1d9n/pdb
PDB entry 1d9n coloured by chain, ensemble of 25 models, front view.
PDB entry 1d9n coloured by chain, ensemble of 25 models, side view.
PDB entry 1d9n coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1.
Ohki I, Shimotake N, Fujita N, Nakao M, Shirakawa M
EMBO J 18 6653-61 (1999)
PMID: 10581239

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methyl-CpG-binding domain protein 1 Chain: A
Molecule details ›
Chain: A
Length: 75 amino acids
Theoretical weight: 8.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UIS9 (Residues: 1-75; Coverage: 12%)
Gene names: CXXC3, MBD1, PCM1
Sequence domains: Methyl-CpG binding domain
Structure domains: Methyl-cpg-binding Protein 2; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: STRUCTURE CALCULATIONS WERE PERFORMED FOLLOWING SIMULATED ANNEALING PROTOCOLS USING X-PLOR 3.8.
Expression system: Escherichia coli

Quick links

Citations

27 review citations

The methyl-CpG binding domain and the evolving role of DNA methylation in animals.
Hendrich et al. (2003)
26 more

2 mentions without citation

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.
Anosova et al. (2015)
1 more