› 1db2

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1

Released:
DOI: 10.2210/pdb1db2/pdb
PDB entry 1db2 coloured by chain, front view.
PDB entry 1db2 coloured by chain, side view.
PDB entry 1db2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
Nar H, Bauer M, Stassen JM, Lang D, Gils A, Declerck PJ
J Mol Biol 297 683-95 (2000)
PMID: 10731421

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 377 amino acids
Theoretical weight: 42.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05121 (Residues: 26-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P3121
Unit cell:
a: 92.6Å b: 92.6Å c: 251.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.255 0.299
Expression system: Escherichia coli

Quick links

Citations

4 review citations

New insights into the molecular mechanisms of the fibrinolytic system.
Rijken et al. (2009)
3 more

11 mentions without citation

Protein metamorphosis: the two-state behavior of Mad2.
Luo et al. (2008)
10 more