› 1dbh

X-ray diffraction
2.3Å resolution

DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1

Released:
DOI: 10.2210/pdb1dbh/pdb
PDB entry 1dbh coloured by chain, front view.
PDB entry 1dbh coloured by chain, side view.
PDB entry 1dbh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J
Cell 95 259-68 (1998)
PMID: 9790532

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Son of sevenless homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 41.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q07889 (Residues: 198-551; Coverage: 27%)
Gene name: SOS1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 104.4Å b: 70.44Å c: 73.83Å
α: 90° β: 96.29° γ: 90°
R-values:
R R work R free
0.229 0.229 0.269
Expression system: Escherichia coli BL21

Quick links

Citations

31 review citations

Rho GTPases and their effector proteins.
Bishop et al. (2000)
30 more

5 mentions without citation

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.
Kiel et al. (2014)
4 more