› 1deb

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF THE N-TERMINAL COILED COIL DOMAIN FROM APC

Released:
DOI: 10.2210/pdb1deb/pdb
PDB entry 1deb coloured by chain, front view.
PDB entry 1deb coloured by chain, side view.
PDB entry 1deb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor.
Day CL, Alber T
J Mol Biol 301 147-56 (2000)
PMID: 10926498

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-150339 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenomatous polyposis coli protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 54 amino acids
Theoretical weight: 6.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25054 (Residues: 2-55; Coverage: 2%)
Gene names: APC, DP2.5
Sequence domains: Coiled-coil N-terminus of APC, dimerisation domain
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6522
Unit cell:
a: 66.86Å b: 66.86Å c: 127.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.234 0.277
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The β-catenin destruction complex.
Stamos et al. (2013)
6 more

8 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
7 more