› 1dg3

X-ray diffraction
1.8Å resolution

STRUCTURE OF HUMAN GUANYLATE BINDING PROTEIN-1 IN NUCLEOTIDE FREE FORM

Released:
DOI: 10.2210/pdb1dg3/pdb
PDB entry 1dg3 coloured by chain, front view.
PDB entry 1dg3 coloured by chain, side view.
PDB entry 1dg3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins.
Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C
Nature 403 567-71 (2000)
PMID: 10676968

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 592 amino acids
Theoretical weight: 68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P32455 (Residues: 1-592; Coverage: 100%)
Gene name: GBP1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: C2
Unit cell:
a: 155.47Å b: 41.03Å c: 121Å
α: 90° β: 109.42° γ: 90°
R-values:
R R work R free
0.242 0.242 0.276
Expression system: Escherichia coli BL21

Quick links

Citations

55 review citations

The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke et al. (2004)
54 more

21 mentions without citation

The BAR-domain family of proteins: a case of bending and binding?
Habermann B. (2004)
20 more